Selected article for: "IFN treatment and type ifn"
Author: Griffiths, Samantha J.; Koegl, Manfred; Boutell, Chris; Zenner, Helen L.; Crump, Colin M.; Pica, Francesca; Gonzalez, Orland; Friedel, Caroline C.; Barry, Gerald; Martin, Kim; Craigon, Marie H.; Chen, Rui; Kaza, Lakshmi N.; Fossum, Even; Fazakerley, John K.; Efstathiou, Stacey; Volpi, Antonio; Zimmer, Ralf; Ghazal, Peter; Haas, Jürgen
Title: A Systematic Analysis of Host Factors Reveals a Med23-Interferon-? Regulatory Axis against Herpes Simplex Virus Type 1 Replication
  • Document date: 2013_8_8
    • ID: 0lyt8gfq_17
    Snippet: To determine which interferon may be responsible for the antiviral effects of Med23, A549 cells were depleted for Med23 and infected with HSV-1 following pre-stimulation with Type I (IFN-a or IFN-b), Type II (IFN-c) or Type III (the distinct IFN-l1 or the almost identical IFN-l2 and -l3, termed IFN-l2/3) interferons. Whilst treatment with IFN-a, -b and -c significantly decreased HSV-1 replication levels, the observed ,2-fold enhancement of HSV-1 .....
    Document: To determine which interferon may be responsible for the antiviral effects of Med23, A549 cells were depleted for Med23 and infected with HSV-1 following pre-stimulation with Type I (IFN-a or IFN-b), Type II (IFN-c) or Type III (the distinct IFN-l1 or the almost identical IFN-l2 and -l3, termed IFN-l2/3) interferons. Whilst treatment with IFN-a, -b and -c significantly decreased HSV-1 replication levels, the observed ,2-fold enhancement of HSV-1 replication following Med23 depletion was still seen. However, pre-treatment with the both IFN-l1 and IFN-l2/3 blocked the enhancing effect of Med23 depletion (Figure 4b) .

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