Author: Labrie, Marilyne; Lalonde, Simon; Najyb, Ouafa; Thiery, Maxime; Daneault, Caroline; Des Rosiers, Chrisitne; Rassart, Eric; Mounier, Catherine
Title: Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake Document date: 2015_6_17
ID: 0wtq1c15_27
Snippet: In the present study, we used a H-apoD Tg mice where the transgene is driven by the neuron specific Thy-1 promoter (14) . Despite a predominant expression in the central nervous system, a significant mRNA expression was detected in both plasma and liver (for liver, 20% of the level detected in the hippocampus). The H-apoD protein is also detected in the plasma (WT mice were used as a negative control) (0.5 mg /100 ml of plasma) and in liver (0.7 .....
Document: In the present study, we used a H-apoD Tg mice where the transgene is driven by the neuron specific Thy-1 promoter (14) . Despite a predominant expression in the central nervous system, a significant mRNA expression was detected in both plasma and liver (for liver, 20% of the level detected in the hippocampus). The H-apoD protein is also detected in the plasma (WT mice were used as a negative control) (0.5 mg /100 ml of plasma) and in liver (0.7 ng/mg protein) of Tg mice. We also detected the endogenous protein in the blood but not in the liver (S1 Fig) . Therefore, the hepatic H-apoD protein can originate either from an endogenous hepatic expression or from a selective blood uptake.
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