Author: Gwon, Yong-Dae; Strand, Mårten; Lindqvist, Richard; Nilsson, Emma; Saleeb, Michael; Elofsson, Mikael; Överby, Anna K.; Evander, Magnus
Title: Antiviral Activity of Benzavir-2 against Emerging Flaviviruses Document date: 2020_3_22
ID: 0ym40eki_32
Snippet: To explore the anti-ZIKV activity of benzavir-2, we assessed the inhibition of ZsGreen expression after infection of the recombinant ZIKV (rZIKV-ZsGreen). In this recombinant infectious virus, the ZsGreen gene was fused to the sequence encoding foot and mouth disease virus (FMDV) 2A autoprotease and cloned in-between two copies of the sequence encoding ZIKV capsid protein ( Figure 1B ). The infectivity of the rZIKV-ZsGreen was similar compared to.....
Document: To explore the anti-ZIKV activity of benzavir-2, we assessed the inhibition of ZsGreen expression after infection of the recombinant ZIKV (rZIKV-ZsGreen). In this recombinant infectious virus, the ZsGreen gene was fused to the sequence encoding foot and mouth disease virus (FMDV) 2A autoprotease and cloned in-between two copies of the sequence encoding ZIKV capsid protein ( Figure 1B ). The infectivity of the rZIKV-ZsGreen was similar compared to wild-type ZIKV, as previously reported [21] .
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