Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy Document date: 2020_2_27
ID: egntml7e_88
Snippet: VDR was reported to be involved in immunoregulation and resistance to infections via regulating autophagy (Baeke, Takiishi, Korf, Gysemans & Mathieu, 2010; Gois, Ferreira, Olenski & Seguro, 2017) . VDR transcriptionally regulates ATG16L1, which is a target gene and an important autophagy-related protein molecule. If VDR is reduced, ATG16L1 is also reduced associated with abnormal Paneth cells for development of chronic states of mucosal inflammat.....
Document: VDR was reported to be involved in immunoregulation and resistance to infections via regulating autophagy (Baeke, Takiishi, Korf, Gysemans & Mathieu, 2010; Gois, Ferreira, Olenski & Seguro, 2017) . VDR transcriptionally regulates ATG16L1, which is a target gene and an important autophagy-related protein molecule. If VDR is reduced, ATG16L1 is also reduced associated with abnormal Paneth cells for development of chronic states of mucosal inflammation (Sun, 2016) . However, our findings showed that high binding between VDR and ATG16L1 promotor lead to a low protein level of ATG16L1 in LPS tolerance cells, demonstrating VDR negatively regulated the transcription of ATG16L1 in LPS tolerance cells.
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