Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox Document date: 2012_3_1
ID: 0mmtcbof_3
Snippet: Mass immunization with VACV during the smallpox eradication program indicated a critical role for cellular immune responses, since severe complications could occur in patients with T cell deficiencies [31] [32] [33] . However very little information is available on the role of cell-mediated immunity in protective VACV vaccination, although more recent analyses suggest that humans maintain VACV specific T cells for decades after vaccination [34] [.....
Document: Mass immunization with VACV during the smallpox eradication program indicated a critical role for cellular immune responses, since severe complications could occur in patients with T cell deficiencies [31] [32] [33] . However very little information is available on the role of cell-mediated immunity in protective VACV vaccination, although more recent analyses suggest that humans maintain VACV specific T cells for decades after vaccination [34] [35] [36] .
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