Author: Patton, John B.; Bennuru, Sasisekhar; Eberhard, Mark L.; Hess, Jessica A.; Torigian, April; Lustigman, Sara; Nutman, Thomas B.; Abraham, David
Title: Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum Document date: 2018_12_12
ID: 0yh5k6jk_5
Snippet: Several strategies have been employed to overcome murine resistance to infection with various human pathogens. The Collaborative Cross (CC) is a large group of inbred mouse strains that were developed to address many of the different shortcomings found within the existing experimental mouse populations, including small numbers of homozygous strains, limited genetic diversity, and non-ideal population structures. Based on the hypothesis that there.....
Document: Several strategies have been employed to overcome murine resistance to infection with various human pathogens. The Collaborative Cross (CC) is a large group of inbred mouse strains that were developed to address many of the different shortcomings found within the existing experimental mouse populations, including small numbers of homozygous strains, limited genetic diversity, and non-ideal population structures. Based on the hypothesis that there is a genetic basis for mouse susceptibility and resistance to infection, novel strains of CC mice have been identified that are susceptible to specific bacteria, viruses, and parasites of humans [18] [19] [20] [21] [22] [23] .
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