Selected article for: "antigenic drift and multiple wave"
Author: Camacho, Anton; Ballesteros, Sébastien; Graham, Andrea L.; Carrat, Fabrice; Ratmann, Oliver; Cazelles, Bernard
Title: Explaining rapid reinfections in multiple-wave influenza outbreaks: Tristan da Cunha 1971 epidemic as a case study
  • Document date: 2011_12_22
    • ID: 12y420k8_3
    Snippet: Recent findings provide new evidence that supports the role of alternative reinfection mechanisms in driving multiple-wave influenza outbreaks. Notably, a large serological survey conducted during the first wave of the 2009 H1N1 pandemic highlighted host heterogeneity in the efficient development of humoral immunity [9] . This report challenges the assumption that influenza infection confers life-long protection against reinfection by the same st.....
    Document: Recent findings provide new evidence that supports the role of alternative reinfection mechanisms in driving multiple-wave influenza outbreaks. Notably, a large serological survey conducted during the first wave of the 2009 H1N1 pandemic highlighted host heterogeneity in the efficient development of humoral immunity [9] . This report challenges the assumption that influenza infection confers life-long protection against reinfection by the same strain [10] . From a theoretical perspective, it is possible to fit mathematical models in which individuals can be reinfected by the same strain to multiple-wave outbreaks [11, 12] . However, these existing models are rather phenomenological and have been endowed with different biological interpretations, ranging from immune escape by antigenic drift to reinfection by immune deficiency [11, 12] .

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