Author: Brauburger, Kristina; Hume, Adam J.; Mühlberger, Elke; Olejnik, Judith
Title: Forty-Five Years of Marburg Virus Research Document date: 2012_10_1
ID: 0hlj6r10_42
Snippet: Besides its role as a classical matrix protein, MARV VP40 also acts as a virulence factor by counteracting the innate immune response and determining the host tropism for MARV [125, 126] . MARV VP40 blocks the phosphorylation of Janus kinases, which play an important role in multiple signaling pathways by phosphorylating and activating STAT proteins ( Figure 6 )......
Document: Besides its role as a classical matrix protein, MARV VP40 also acts as a virulence factor by counteracting the innate immune response and determining the host tropism for MARV [125, 126] . MARV VP40 blocks the phosphorylation of Janus kinases, which play an important role in multiple signaling pathways by phosphorylating and activating STAT proteins ( Figure 6 ).
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