Author: Okeke, Malachy I.; Okoli, Arinze S.; Diaz, Diana; Offor, Collins; Oludotun, Taiwo G.; Tryland, Morten; Bøhn, Thomas; Moens, Ugo
Title: Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps? Document date: 2017_10_29
ID: 175igdfk_66
Snippet: In this paper, we have highlighted the knowledge gaps and paucity of scientific data on key aspects of MVA biology required for its hazard characterization and presented data obtained in vitro on some worst-case scenarios demonstrating that: (i) MVA productively infects human Caco-2 cells after multiple serial passages in Caco-2 cells and (ii) recombination in vitro between MVA vectored vaccine and a wild type CPXV in a cell line that is semi-per.....
Document: In this paper, we have highlighted the knowledge gaps and paucity of scientific data on key aspects of MVA biology required for its hazard characterization and presented data obtained in vitro on some worst-case scenarios demonstrating that: (i) MVA productively infects human Caco-2 cells after multiple serial passages in Caco-2 cells and (ii) recombination in vitro between MVA vectored vaccine and a wild type CPXV in a cell line that is semi-permissive to MVA. Provision of empirical data to fill in the gaps in knowledge will improve the hazard characterization of MVA-vectored vaccines resulting in a more robust ERA.
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