Author: Smith, Steven B.; Dampier, William; Tozeren, Aydin; Brown, James R.; Magid-Slav, Michal
Title: Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis Document date: 2012_3_14
ID: 100ir651_2
Snippet: While initially effective, pathogen gene targeted treatments exert evolutionary selection on the infectious species often leading to the emergence of drug resistant strains. As a result, there are increasing clinical reports of resistance against many drugs that directly act on viral proteins or their DNA [5, 6] . In particular, resistance to different classes of antiviral drugs is becoming more clinically prevalent in respiratory virus infection.....
Document: While initially effective, pathogen gene targeted treatments exert evolutionary selection on the infectious species often leading to the emergence of drug resistant strains. As a result, there are increasing clinical reports of resistance against many drugs that directly act on viral proteins or their DNA [5, 6] . In particular, resistance to different classes of antiviral drugs is becoming more clinically prevalent in respiratory virus infections as seen with RSV and FLU treated with the antiviral drugs palivizumab [7] , and oseltamivir [8] , respectively.
Search related documents:
Co phrase search for related documents- antiviral drug and pathogen gene: 1
- antiviral drug and resistant strain: 1, 2, 3, 4
- antiviral drug and respiratory virus infection: 1, 2, 3, 4, 5, 6, 7
- antiviral drug and treatment target: 1, 2, 3, 4, 5, 6, 7
- antiviral drug and viral protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64
- antiviral drug and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- clinical report and respiratory virus infection: 1, 2, 3, 4, 5, 6, 7
- clinical report and viral protein: 1, 2
- clinical report and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34
- different class and resistant strain: 1
- different class and viral protein: 1, 2, 3
- different class and virus infection: 1, 2, 3
- drug resistant strain and resistant strain: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- drug resistant strain emergence and resistant strain: 1, 2
- evolutionary selection and resistant strain: 1, 2
- evolutionary selection and viral protein: 1, 2, 3, 4
- evolutionary selection and virus infection: 1, 2
- pathogen gene and virus infection: 1, 2
- resistant strain and viral protein: 1, 2
Co phrase search for related documents, hyperlinks ordered by date