Author: Smith, Steven B.; Dampier, William; Tozeren, Aydin; Brown, James R.; Magid-Slav, Michal
Title: Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis Document date: 2012_3_14
ID: 100ir651_39
Snippet: As mentioned above, CASP1 is a component of the NLRP3 inflammasome, activating the precursor to IL1B [69] . Therefore, a CASP1 inhibitor would have an antagonist relationship with IL1B, hence the inflammasome. Further, CASP1 inhibitors would be agonists for PARK2, thereby reducing accumulation of SNCA. In this regard, CASP1 inhibitors may not only prevent unnecessary NLRP3 inflammasome activation via ILB1, but may also reduce accumulation of neur.....
Document: As mentioned above, CASP1 is a component of the NLRP3 inflammasome, activating the precursor to IL1B [69] . Therefore, a CASP1 inhibitor would have an antagonist relationship with IL1B, hence the inflammasome. Further, CASP1 inhibitors would be agonists for PARK2, thereby reducing accumulation of SNCA. In this regard, CASP1 inhibitors may not only prevent unnecessary NLRP3 inflammasome activation via ILB1, but may also reduce accumulation of neurotoxic Lewy bodies through activation of PARK2.
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