Author: Kumar, Satyendra; Arankalle, Vidya A.
Title: Intracranial Administration of P Gene siRNA Protects Mice from Lethal Chandipura Virus Encephalitis Document date: 2010_1_7
ID: 1mzq227n_3
Snippet: Several studies have shown that the central nervous system (CNS) is also acquiescent to RNAi as in the case of brain cancer [18] , Spinocerebellar ataxia [19] . Intracranial injection of siRNA has shown immense potential in suppressing encephalitis caused by two flaviviruses, JEV (Japanese encephalitis virus) and WNV (West Nile virus) [20] . Control of non-segmented negative-strand RNA virus replication in culture cells by siRNA has been well doc.....
Document: Several studies have shown that the central nervous system (CNS) is also acquiescent to RNAi as in the case of brain cancer [18] , Spinocerebellar ataxia [19] . Intracranial injection of siRNA has shown immense potential in suppressing encephalitis caused by two flaviviruses, JEV (Japanese encephalitis virus) and WNV (West Nile virus) [20] . Control of non-segmented negative-strand RNA virus replication in culture cells by siRNA has been well documented [21] . A recent study has shown inhibition of rabies virus replication by multiple artificial microRNAs (amiRNA) in Neuro 2a cells [22] .
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