Author: McCarthy, Mary K.; Reynoso, Glennys V.; Winkler, Emma S.; Mack, Matthias; Diamond, Michael S.; Hickman, Heather D.; Morrison, Thomas E.
Title: MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2 Document date: 2020_1_30
ID: 1tut4erh_36
Snippet: In summary, we found that a rapid influx of Ly6C hi monocytes and neutrophils to the dLN impairs lymphocyte accumulation, dLN organization, and downstream antiviral B cell responses to pathogenic CHIKV infection in a manner partially dependent on Nos2 and Nox2. Furthermore, we identified a role for MyD88-dependent IRF5-driven type I IFN signaling in the dLN that promotes iNOS expression in infiltrating monocytes. Our findings reveal an additional.....
Document: In summary, we found that a rapid influx of Ly6C hi monocytes and neutrophils to the dLN impairs lymphocyte accumulation, dLN organization, and downstream antiviral B cell responses to pathogenic CHIKV infection in a manner partially dependent on Nos2 and Nox2. Furthermore, we identified a role for MyD88-dependent IRF5-driven type I IFN signaling in the dLN that promotes iNOS expression in infiltrating monocytes. Our findings reveal an additional mechanism that dampens the development of the anti-CHIKV Ab response during pathogenic CHIKV infection, and underscore how local innate immune responses in draining lymphoid tissue dictate the magnitude of downstream adaptive immunity.
Search related documents:
Co phrase search for related documents- dLN impairs lymphocyte accumulation and rapid influx: 1
- dln signal and pathogenic CHIKV infection: 1
- immune response and inos expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- immune response and lymphoid tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33
- inos expression and lymphoid tissue: 1, 2, 3, 4
- inos expression and pathogenic CHIKV infection: 1, 2, 3, 4, 5, 6
- inos expression and rapid influx: 1
- lymphoid tissue and pathogenic CHIKV infection: 1, 2
- pathogenic CHIKV infection and rapid influx: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date