Author: McCarthy, Mary K.; Reynoso, Glennys V.; Winkler, Emma S.; Mack, Matthias; Diamond, Michael S.; Hickman, Heather D.; Morrison, Thomas E.
Title: MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2 Document date: 2020_1_30
ID: 1tut4erh_36
Snippet: In summary, we found that a rapid influx of Ly6C hi monocytes and neutrophils to the dLN impairs lymphocyte accumulation, dLN organization, and downstream antiviral B cell responses to pathogenic CHIKV infection in a manner partially dependent on Nos2 and Nox2. Furthermore, we identified a role for MyD88-dependent IRF5-driven type I IFN signaling in the dLN that promotes iNOS expression in infiltrating monocytes. Our findings reveal an additional.....
Document: In summary, we found that a rapid influx of Ly6C hi monocytes and neutrophils to the dLN impairs lymphocyte accumulation, dLN organization, and downstream antiviral B cell responses to pathogenic CHIKV infection in a manner partially dependent on Nos2 and Nox2. Furthermore, we identified a role for MyD88-dependent IRF5-driven type I IFN signaling in the dLN that promotes iNOS expression in infiltrating monocytes. Our findings reveal an additional mechanism that dampens the development of the anti-CHIKV Ab response during pathogenic CHIKV infection, and underscore how local innate immune responses in draining lymphoid tissue dictate the magnitude of downstream adaptive immunity.
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