Author: Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric
Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus Document date: 2016_4_21
ID: 0a20s62q_44
Snippet: In addition, studying CCHFV glycoprotein function is a critical area of research due to the significant gaps in our knowledge of the essential roles of the glycoproteins in the viral replication cycle. Improved knowledge of glycoprotein processing may provide targeted development of medical countermeasures. Since furin has a relatively minor role in the CCHFV replication cycle compared to SKI-1/S1P, pharmacological inhibitors of SKI-1/S1P may rep.....
Document: In addition, studying CCHFV glycoprotein function is a critical area of research due to the significant gaps in our knowledge of the essential roles of the glycoproteins in the viral replication cycle. Improved knowledge of glycoprotein processing may provide targeted development of medical countermeasures. Since furin has a relatively minor role in the CCHFV replication cycle compared to SKI-1/S1P, pharmacological inhibitors of SKI-1/S1P may represent a promising drug target. Efficacy studies of proprotein convertase inhibitors in vivo and in vitro are critically needed to better assess the therapeutic potential of furin and SKI-1/S1P inhibition.
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