Author: Melnik, Lilia I; Garry, Robert F; Morris, Cindy A
Title: Peptide inhibition of human cytomegalovirus infection Document date: 2011_2_22
ID: 0p6x4lwx_3
Snippet: Antibodies to HCMV gB have been shown not only to block penetration of virions into cells, but also to limit cell-to-cell infection, implying that gB plays a role in virion penetration into cells, cell-to-cell transmission, as well as fusion of infected cells [20, 22] . Recently, Isaacson and coworkers used genetic complementation to confirm that gB is required for the fusion of viral and cellular membranes, virus entry, and cell-to-cell spread o.....
Document: Antibodies to HCMV gB have been shown not only to block penetration of virions into cells, but also to limit cell-to-cell infection, implying that gB plays a role in virion penetration into cells, cell-to-cell transmission, as well as fusion of infected cells [20, 22] . Recently, Isaacson and coworkers used genetic complementation to confirm that gB is required for the fusion of viral and cellular membranes, virus entry, and cell-to-cell spread of HCMV [23] . The importance of gB for viral infection suggests that this viral envelope protein may be a rational target for novel drug design.
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