Author: Pinheiro, Aruanã Joaquim Matheus Costa Rodrigues; Gonçalves, Jaciara Sá; Dourado, Ádylla Wilenna Alves; de Sousa, Eduardo Martins; Brito, Natilene Mesquita; Silva, Lanna Karinny; Batista, Marisa Cristina Aranha; de Sá, Joicy Cortez; Monteiro, Cinara Regina Aragão Vieira; Fernandes, Elizabeth Soares; Monteiro-Neto, Valério; Campbell, Lee Ann; Zago, Patrícia Maria Wiziack; Lima-Neto, Lidio Gonçalves
Title: Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury Document date: 2018_2_20
ID: 0e9lq1b5_2
Snippet: Punica granatum L. (pomegranate) has been shown to possess wound healing, antimicrobial, antioxidant, and antiinflammatory properties [6] [7] [8] . Especially due to its antiinflammatory activities, pomegranate is traditionally used to treat infections. In this context, we recently demonstrated that the leaf hydroalcoholic extract obtained from pomegranate is anti-inflammatory as it inhibits TNF-α production and decreases neutrophil migration in.....
Document: Punica granatum L. (pomegranate) has been shown to possess wound healing, antimicrobial, antioxidant, and antiinflammatory properties [6] [7] [8] . Especially due to its antiinflammatory activities, pomegranate is traditionally used to treat infections. In this context, we recently demonstrated that the leaf hydroalcoholic extract obtained from pomegranate is anti-inflammatory as it inhibits TNF-α production and decreases neutrophil migration in a rat model of lipopolysaccharide-(LPS-) induced acute peritonitis [8] . Furthermore, Haseeb et al. showed that the pomegranate fruit extract attenuates IL-6 production, reactive oxygen species, IL-1βmediated phosphorylation of the inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ), expression of IKKβ mRNA, degradation of IκBα, and the activation and nuclear translocation of NF-κB/p65 in human chondrocytes [9] .
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