Selected article for: "airway inflammation and copd asthma"
Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside
  • Document date: 2016_9_20
    • ID: 04pp3lv0_61
    Snippet: Despite similar clinical features, the mechanisms of underlying airway inflammation in asthma and COPD are different with distinct patterns of inflammatory cells and mediators being involved [163] . The mechanisms and the mediators that drive the progression of chronic inflammation and emphysema in COPD are far from fully understood [208] . The major signaling factors involved in the pathogenesis of COPD include TNF-α, CCL2, CXCL8, TGF-β and VE.....
    Document: Despite similar clinical features, the mechanisms of underlying airway inflammation in asthma and COPD are different with distinct patterns of inflammatory cells and mediators being involved [163] . The mechanisms and the mediators that drive the progression of chronic inflammation and emphysema in COPD are far from fully understood [208] . The major signaling factors involved in the pathogenesis of COPD include TNF-α, CCL2, CXCL8, TGF-β and VEGF [206] . Many of the cytokines and chemokines secreted in the airways of COPD patients are modulated by the NF-κB pathway [163] . Therefore, RNAi targeting NF-κB pathway can be a strategy for the management of COPD [176, 209] .

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