Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site Document date: 2015_3_25
ID: 10p3mth2_3
Snippet: Despite intensive investigation, the molecular details of −1 PRF remain uncertain, with at least five plausible models proposed. Recently, kinetic studies have indicated that the ribosome may be induced into a conformation that disfavours translocation prior to −1 PRF [30] , [31] . In most of these models, the heptanucleotide slippery sequence occupies the A and P sites of the ribosome as frameshifting occurs [15] , [32] ......
Document: Despite intensive investigation, the molecular details of −1 PRF remain uncertain, with at least five plausible models proposed. Recently, kinetic studies have indicated that the ribosome may be induced into a conformation that disfavours translocation prior to −1 PRF [30] , [31] . In most of these models, the heptanucleotide slippery sequence occupies the A and P sites of the ribosome as frameshifting occurs [15] , [32] .
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