Author: Fan, Qing; Kopp, Sarah J.; Connolly, Sarah A.; Longnecker, Richard
Title: Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype Document date: 2017_5_16
ID: 1v6nf28a_2
Snippet: Fusion of the viral membrane with the host cell membrane is executed by gB, a class III viral fusion protein (12) that is conserved across all herpesviruses (13) . Viral fusion proteins initially fold to a metastable prefusion state. Upon triggering, the proteins insert themselves into the cellular membrane and refold from a prefusion to a postfusion conformation to bring the viral and cell membranes together. Crystal structures of the postfusion.....
Document: Fusion of the viral membrane with the host cell membrane is executed by gB, a class III viral fusion protein (12) that is conserved across all herpesviruses (13) . Viral fusion proteins initially fold to a metastable prefusion state. Upon triggering, the proteins insert themselves into the cellular membrane and refold from a prefusion to a postfusion conformation to bring the viral and cell membranes together. Crystal structures of the postfusion gB conformation have been solved for three herpesviruses (12, (14) (15) (16) . The prefusion conformation of gB and the details of how it refolds to execute fusion are unclear. Attempts to capture a stable prefusion form of HSV-1 gB for crystallization have been unsuccessful (17) .
Search related documents:
Co phrase search for related documents- cell viral membrane and fusion execute: 1
- cell viral membrane and fusion protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell viral membrane and gB conformation: 1
- cell viral membrane and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell viral membrane and host cell membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell viral membrane and host cell membrane viral membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell viral membrane and host cell membrane viral membrane fusion: 1, 2, 3, 4, 5, 6, 7, 8
- cell viral membrane and postfusion conformation: 1, 2, 3
- cell viral membrane bring and host cell: 1
- cell viral membrane bring and host cell membrane: 1
- cell viral membrane bring and host cell membrane viral membrane: 1
- cell viral membrane bring and host cell membrane viral membrane fusion: 1
- cellular membrane and crystal structure: 1, 2, 3, 4, 5
- cellular membrane and fusion protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cellular membrane and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cellular membrane and host cell membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- cellular membrane and postfusion conformation: 1
- crystal structure and fusion protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- crystal structure and gB conformation: 1
Co phrase search for related documents, hyperlinks ordered by date