Author: Law, Helen KW; Cheung, Chung Yan; Sia, Sin Fun; Chan, Yuk On; Peiris, JS Malik; Lau, Yu Lung
Title: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells Document date: 2009_6_8
ID: 19noki6p_10
Snippet: Gene expression of intracellular TLRs (TLR-3, TLR-7, TLR-8, TLR-9) in DCs are summarised in Fig. 2 . In adult DCs, the expression was low (average in range of 0 -20 copies per 10 4 β-actin). The expression of TLR-3, TLR-7 and TLR-9 were also low in CB DCs (average in range of 0 -20 copies per 10 4 β-actin). The basal gene expression of TLR-8 was high in CB DCs and the expression was nearly doubled after SARS-CoV infection at both 3 h and 9 h po.....
Document: Gene expression of intracellular TLRs (TLR-3, TLR-7, TLR-8, TLR-9) in DCs are summarised in Fig. 2 . In adult DCs, the expression was low (average in range of 0 -20 copies per 10 4 β-actin). The expression of TLR-3, TLR-7 and TLR-9 were also low in CB DCs (average in range of 0 -20 copies per 10 4 β-actin). The basal gene expression of TLR-8 was high in CB DCs and the expression was nearly doubled after SARS-CoV infection at both 3 h and 9 h post infection. However, due to sample variations the difference between mock and SARS-CoV infected CB DCs was not statistically significant.
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