Selected article for: "amino acid residue and MERS cov"
Author: Lau, Susanna K. P.; Wong, Antonio C. P.; Lau, Terrence C. K.; Woo, Patrick C. Y.
Title: Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir?
  • Document date: 2017_10_16
    • ID: 1sq2uvur_25
    Snippet: The models of spike glycoprotein from each clade were built. It was observed that the amino acid substitutions observed by multiple alignments appeared to be randomly distributed throughout the structure ( Figure 6 ). Based on the model, we did not observe specific evolutionary patterns of the MERS-CoV spike protein. However, intriguingly, the residue at position 1020 can distinguish between clade A and B (Figure 4 ). The glutamine (Q1020) and ar.....
    Document: The models of spike glycoprotein from each clade were built. It was observed that the amino acid substitutions observed by multiple alignments appeared to be randomly distributed throughout the structure ( Figure 6 ). Based on the model, we did not observe specific evolutionary patterns of the MERS-CoV spike protein. However, intriguingly, the residue at position 1020 can distinguish between clade A and B (Figure 4 ). The glutamine (Q1020) and arginine residues (R1020) at that position are highly conserved in clade A and clade B, respectively, except for a histidine residue (H1020) found in 12 lineage B5 strains. Together with results from selective pressure analysis, this suggests that this amino acid residue may play a role during the molecular evolution of S protein of MERS-CoV and divergence of different lineages.

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