Selected article for: "amino acid residue role play and histidine residue"
Author: Lau, Susanna K. P.; Wong, Antonio C. P.; Lau, Terrence C. K.; Woo, Patrick C. Y.
Title: Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir?
  • Document date: 2017_10_16
    • ID: 1sq2uvur_25
    Snippet: The models of spike glycoprotein from each clade were built. It was observed that the amino acid substitutions observed by multiple alignments appeared to be randomly distributed throughout the structure ( Figure 6 ). Based on the model, we did not observe specific evolutionary patterns of the MERS-CoV spike protein. However, intriguingly, the residue at position 1020 can distinguish between clade A and B (Figure 4 ). The glutamine (Q1020) and ar.....
    Document: The models of spike glycoprotein from each clade were built. It was observed that the amino acid substitutions observed by multiple alignments appeared to be randomly distributed throughout the structure ( Figure 6 ). Based on the model, we did not observe specific evolutionary patterns of the MERS-CoV spike protein. However, intriguingly, the residue at position 1020 can distinguish between clade A and B (Figure 4 ). The glutamine (Q1020) and arginine residues (R1020) at that position are highly conserved in clade A and clade B, respectively, except for a histidine residue (H1020) found in 12 lineage B5 strains. Together with results from selective pressure analysis, this suggests that this amino acid residue may play a role during the molecular evolution of S protein of MERS-CoV and divergence of different lineages.

    Search related documents:
    Co phrase search for related documents
    • amino acid and different lineage: 1, 2, 3, 4
    • amino acid and evolutionary pattern: 1, 2, 3, 4, 5
    • amino acid and histidine residue: 1, 2, 3, 4, 5, 6, 7, 8
    • amino acid and MERS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid and MERS cov spike protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • amino acid and molecular evolution: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid and multiple alignment: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid residue and histidine residue: 1, 2
    • amino acid residue and MERS cov: 1, 2, 3, 4
    • amino acid residue and MERS cov spike protein: 1
    • amino acid residue and molecular evolution: 1
    • amino acid residue and multiple alignment: 1
    • amino acid residue role play and histidine residue: 1
    • amino acid residue role play and MERS cov: 1
    • amino acid residue role play and MERS cov spike protein: 1
    • amino acid residue role play and molecular evolution: 1
    • amino acid substitution and histidine residue: 1, 2, 3
    • amino acid substitution and MERS cov: 1, 2, 3, 4, 5, 6, 7
    • amino acid substitution and multiple alignment: 1, 2, 3, 4