Author: Smith, Steven B.; Dampier, William; Tozeren, Aydin; Brown, James R.; Magid-Slav, Michal
Title: Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis Document date: 2012_3_14
ID: 100ir651_1
Snippet: Respiratory viruses account for seasonal colds, bronchiolitis, acute otitis, sinusitis, croup, community-acquired pneumonia, and exacerbation of both chronic obstructive pulmonary disease and asthma [1] . The prevalence of pandemic Orthomyxoviridae Influenza A Virus (FLU) from April 2009 to 2010 was estimated to be approximately 60 million cases, 270,000 hospitalizations, and 12,000 deaths [2] . Paramyxoviridae Respiratory Syncytial Virus (RSV) i.....
Document: Respiratory viruses account for seasonal colds, bronchiolitis, acute otitis, sinusitis, croup, community-acquired pneumonia, and exacerbation of both chronic obstructive pulmonary disease and asthma [1] . The prevalence of pandemic Orthomyxoviridae Influenza A Virus (FLU) from April 2009 to 2010 was estimated to be approximately 60 million cases, 270,000 hospitalizations, and 12,000 deaths [2] . Paramyxoviridae Respiratory Syncytial Virus (RSV) infection results in nearly two million children requiring medical care with about 57,000 children younger than five years hospitalized annually [3] . In one survey, RSV was the most prevalent pathogen in children under five years with an acute respiratory infection, followed by Adenoviridae adenovirus (ADENO), and Picornaviridae human rhinovirus (HRV) [4] .
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