Selected article for: "feline immunodeficiency virus and immunodeficiency virus"
Author: Joshua A. Hayward; Mary Tachedjian; Adam Johnson; Tamsin B. Gordon; Jie Cui; Glenn A. Marsh; Michelle L. Baker; Lin-Fa Wang; Gilda Tachedjian
Title: Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin
  • Document date: 2020_4_9
    • ID: eksi9yia_35
    Snippet: The one bat species, T. melanopogon, that lacked the human l-tetherin homolog, possessed an equivalent of the short isoform of human tetherin (s-tetherin), an observation also reported for cats (44) . In a study of feline tetherin, short isoformexclusivity was found to improve viral restriction and decrease sensitivity to tetherin antagonism by HIV-1 Vpu when compared to an engineered long isoform version of feline tetherin (44) . Conversely, the.....
    Document: The one bat species, T. melanopogon, that lacked the human l-tetherin homolog, possessed an equivalent of the short isoform of human tetherin (s-tetherin), an observation also reported for cats (44) . In a study of feline tetherin, short isoformexclusivity was found to improve viral restriction and decrease sensitivity to tetherin antagonism by HIV-1 Vpu when compared to an engineered long isoform version of feline tetherin (44) . Conversely, the feline immunodeficiency virus (FIV), which is adapted to the feline host, is not restricted by either long or short isoforms of feline tetherin (44) .

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