Selected article for: "blood plasma and human blood plasma"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_24
    Snippet: In conclusion, the data reported suggest that there are meaningful changes in box C/D and box H/ACA snoRNA levels in human cells and body fluids during the development of oncological diseases. Small nucleolar RNAs were suggested both as biomarkers of oncological diseases and as targets for cancer therapy. Other ncRNAs, first of all circulating in human blood plasma microRNAs, have been considered to be perspective minimally invasive markers of di.....
    Document: In conclusion, the data reported suggest that there are meaningful changes in box C/D and box H/ACA snoRNA levels in human cells and body fluids during the development of oncological diseases. Small nucleolar RNAs were suggested both as biomarkers of oncological diseases and as targets for cancer therapy. Other ncRNAs, first of all circulating in human blood plasma microRNAs, have been considered to be perspective minimally invasive markers of diseases [61] [62] [63] [64] [65] [66] . Thus, small nucleolar RNAs supplement the set of therapeutically and diagnostically significant regulatory RNAs, and the fundamental knowledge of snoRNA structure and biological functions can be applied to the development of new therapeutic approaches for cancer treatment.

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