Author: Basso, Maria Alexandra; Marques, Cátia; Santos, Marcos; Duarte, Ana; Pissarra, Hugo; Carreira, L Miguel; Gomes, Lídia; Valério-Bolas, Ana; Tavares, Luís; Santos-Gomes, Gabriela; Pereira da Fonseca, Isabel
Title: Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate Document date: 2016_2_10
ID: k9booi08_8
Snippet: The cat was treated orally with 10 mg/kg allopurinol q12h and a three-layered bandage was applied to the four limbs. Medical follow-up was performed every 2 days during the first fortnight. After 15 days of treatment with allopurinol only a slight clinical improvement was noted. Fever persisted and skin ulcers seemed equally profound. Therefore, a combined therapeutic protocol not yet approved for cats was suggested to the owner. N-methyl-glucami.....
Document: The cat was treated orally with 10 mg/kg allopurinol q12h and a three-layered bandage was applied to the four limbs. Medical follow-up was performed every 2 days during the first fortnight. After 15 days of treatment with allopurinol only a slight clinical improvement was noted. Fever persisted and skin ulcers seemed equally profound. Therefore, a combined therapeutic protocol not yet approved for cats was suggested to the owner. N-methyl-glucamine antimoniate administration is off-label in cats, with only a few published cases of FeL treated with this drug. After owner consent was obtained, treatment was reinforced with 50 mg/kg N-methyl-glucamine antimoniate (Glucantime; Merial) q24h SC for 30 consecutive days. This study was conducted in the framework of FCT Project PTDC/CVT/118566/2010, with the agreement of the Ethics Committee and Animal Welfare of the Faculty of Veterinary Medicine, University of Lisbon.
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