Selected article for: "secondary structure and SRE structure"
Author: William Rodriguez; Aman Srivastav; Mandy Muller
Title: C19ORF66 broadly escapes viral-induced endonuclease cleavage and restricts Kaposi’s Sarcoma Associated Herpesvirus (KSHV)
  • Document date: 2018_12_26
    • ID: 5a4i8v59_23
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. reveal that a cluster of 75 host transcripts can systematically escape viral-induced 227 endonucleolytic cleavage. We hypothesize that these may contain similar RNA escape elements 228 as the one we previously characterized in IL-6 and GADD45B and therefore could be important 229 regulators of the viral-host interplay. IL-6 and GADD45B escape elements (refe.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. reveal that a cluster of 75 host transcripts can systematically escape viral-induced 227 endonucleolytic cleavage. We hypothesize that these may contain similar RNA escape elements 228 as the one we previously characterized in IL-6 and GADD45B and therefore could be important 229 regulators of the viral-host interplay. IL-6 and GADD45B escape elements (referred to as SRE 230 and G-SRE respectively) were shown to adopt a specific secondary structure that we 231 hypothesized to be crucial in recruiting host protein to the 3'UTR of these escaping transcripts 232

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