Author: Noh, Heeju; Shoemaker, Jason E; Gunawan, Rudiyanto
Title: Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection Document date: 2018_4_6
ID: j80hnhpb_20
Snippet: By taking the pseudo steady-state assumption (i.e. the synthesis rate of mRNA balances the degradation rate, leading to dr k /dt = 0 in Equation (3)), the inference of edge weights (a * kj ) of the PGRN can be rewritten as the following linear regression problem (see derivation in (10)):.....
Document: By taking the pseudo steady-state assumption (i.e. the synthesis rate of mRNA balances the degradation rate, leading to dr k /dt = 0 in Equation (3)), the inference of edge weights (a * kj ) of the PGRN can be rewritten as the following linear regression problem (see derivation in (10)):
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