2015 ACVIM Forum Research Abstract Program

The administration with mirtazapine significantly reduced the post-CRH ACTH concentrations but not the cortisol concentrations. Post-ACTH cortisol concentrations were significantly reduced by the administration with mirtazapine, but no significant differences in the basal ACTH and cortisol concentrations were revealed. Serum serotonin concentrations were significantly increased by the administration of mirtazapin, and leptin concentrations were reduced significantly during mirtazapine administration periods; the lowest levels were observed at day 7. These results suggested that mirtazapine had a short-term suppressive effect on the HPA axis in healthy dogs. In addition, serum serotonin and leptin levels might be influenced by mirtazapine administration.