Author: McWhirter, Sarah M.; Barbalat, Roman; Monroe, Kathryn M.; Fontana, Mary F.; Hyodo, Mamoru; Joncker, Nathalie T.; Ishii, Ken J.; Akira, Shizuo; Colonna, Marco; Chen, Zhijian J.; Fitzgerald, Katherine A.; Hayakawa, Yoshihiro; Vance, Russell E.
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP Document date: 2009_8_31
ID: 3b8b8p61_21
Snippet: We validated our results by examining production of a second secreted molecule known to be a target of the Tbk1-Irf3 signaling axis, the chemokine Rantes (Ccl5). Rantes production was assessed by ELISA (Fig. S1 ). As expected, we found that Rantes was induced by c-di-GMP in a manner dependent on Tbk1, Irf3, and Ifnar, but largely or entirely independent of MyD88/Trif, Irf1, Irf5, Irf7, or Mavs (Fig. S1 )......
Document: We validated our results by examining production of a second secreted molecule known to be a target of the Tbk1-Irf3 signaling axis, the chemokine Rantes (Ccl5). Rantes production was assessed by ELISA (Fig. S1 ). As expected, we found that Rantes was induced by c-di-GMP in a manner dependent on Tbk1, Irf3, and Ifnar, but largely or entirely independent of MyD88/Trif, Irf1, Irf5, Irf7, or Mavs (Fig. S1 ).
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