Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_390
Snippet: Of all tested drugs, metoclopramide caused the most pronounced and sustained increase in MI both before and after a meal. Fasted MI was increased for all other dugs, however postprandial MI was mostly unchanged. Metoclopramide is the antiemetic drug with the highest prokinetic activity in the gastric antrum. The abnormal interaction between the GI microbiome and the immune system is thought to be a major contributing factor to the etiology of inf.....
Document: Of all tested drugs, metoclopramide caused the most pronounced and sustained increase in MI both before and after a meal. Fasted MI was increased for all other dugs, however postprandial MI was mostly unchanged. Metoclopramide is the antiemetic drug with the highest prokinetic activity in the gastric antrum. The abnormal interaction between the GI microbiome and the immune system is thought to be a major contributing factor to the etiology of inflammatory bowel disease (IBD). Treatment of canine IBD often includes judicious use of antimicrobials such as metronidazole. The aim of this study was to prospectively evaluate the impact of metronidazole administration on the fecal microbiome of healthy dogs.
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