Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_620
Snippet: These results suggest the initial D-PNa had the best correlation with the final PNa. It has potential to be used in the prescription of DNa to correct disorders in pre-dialysis sodium concentration and prediction of the final PNa. Chronic kidney disease (CKD) is a common condition of aging cats, with the predominant pathological diagnosis being tubulointerstitial inflammation and fibrosis. The cytokine TGF-b1 has been widely implicated in the dev.....
Document: These results suggest the initial D-PNa had the best correlation with the final PNa. It has potential to be used in the prescription of DNa to correct disorders in pre-dialysis sodium concentration and prediction of the final PNa. Chronic kidney disease (CKD) is a common condition of aging cats, with the predominant pathological diagnosis being tubulointerstitial inflammation and fibrosis. The cytokine TGF-b1 has been widely implicated in the development and progression of renal fibrosis in experimental models of kidney disease, and total TGF-b1 has been demonstrated to be elevated in the urine of cats with CKD. The aims of this study were: firstly, to validate a method for the quantification of active TGF-b1 in feline urine; secondly, to assess the association between urinary active TGF-b1 and (a) the development of azotemic CKD in a cross-sectional study and (b) the deterioration of renal function in a longitudinal study.
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