Author: Beigel, John H.; Tebas, Pablo; Elie-Turenne, Marie-Carmelle; Bajwa, Ednan; Bell, Todd E.; Cairns, Charles B.; Shoham, Shmuel; Deville, Jaime G.; Feucht, Eric; Feinberg, Judith; Luke, Thomas; Raviprakash, Kanakatte; Danko, Janine; O’Neil, Dorothy; Metcalf, Julia A.; King, Karen; Burgess, Timothy H.; Aga, Evgenia; Lane, H. Clifford; Hughes, Michael D.; Davey, Richard T.
Title: A Randomized Study of Immune Plasma for the Treatment of Severe Influenza Document date: 2017_5_15
ID: 2g22oqf2_21
Snippet: Ninety-eight participants were randomized. Eleven participants were excluded from the Primary Efficacy Population (PEP) because their initial samples were PCR negative by central laboratory testing. The median age of the randomized participants was 53 years (range 0-95 years). Eleven children and two pregnant women were enrolled ( Table 1 ). The majority of participants had underlying medical conditions, with hypertension and chronic pulmonary di.....
Document: Ninety-eight participants were randomized. Eleven participants were excluded from the Primary Efficacy Population (PEP) because their initial samples were PCR negative by central laboratory testing. The median age of the randomized participants was 53 years (range 0-95 years). Eleven children and two pregnant women were enrolled ( Table 1 ). The majority of participants had underlying medical conditions, with hypertension and chronic pulmonary disease being the most common (medical conditions present in ≥ 10% of participants are presented in Table 1 ). Participants had a median 4 days of influenza illness prior to enrollment, and 61% (N=60) had received antivirals prior to randomization (median 2 days of antivirals prior to enrollment). All participants received antibiotics (the protocol did not dictate which antibiotics would be used). No participants received naproxen, and only 6 participants received azithromycin.
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