2016 ACVIM Forum Research Abstract Program

Forty-three client-owned dogs were included. Median initial serum creatinine (iSCr) was 8.5 [3.6 -16.6] mg/dl and median age at presentation was 5.6 [0.70 -13.5] years. Eighteen were male neutered, 14 were female spayed, 4 were intact male, and 7 were intact female dogs. At 30 days, 30/43 dogs (70%) were alive (iSCr, ] mg/dl) and 13/43 (30%) had died or been euthanized (iSCr, ] mg/dl). Nine of 30 dogs (30%) were still dialysis dependent at 30 days (iSCr, ] mg/dl), and 21/30 (70%) were non dialysis-dependent (iSCr, -1001] mcg/L, P = 0.008). The proportion of dogs alive at 30 days with SPEC ≥ 400 mcg/L during the treatment course was not different from alive dogs with SPEC < 400 mcg/L (71% versus 68%, P = 1.0). In addition, the proportion of the non dialysis-dependent dogs with SPEC ≥ 400 mcg/L during the treatment course was not different from non dialysis-dependent dogs with SPEC < 400 mcg/ L (42% versus 58%, P = 0.36). These results suggest the presence of pancreatitis assessed as SPEC ≥ 400 mcg/L did not affect survival outcome at 30 days. However, pancreatitis may be a more common co-morbidity in dogs with more severe (dialysis-dependent) AKI and it may influence renal recovery. Bacterial urinary tract infection (UTI) is common in dogs, however the prevalence of subclinical bacteriuria (SBU) in healthy dogs has recently been demonstrated to be substantially lower. Following standards created by human infectious disease specialists, there has been more initiative put towards identifying and characterizing SBU in dogs. Although it has been considered a risk factor for UTI, the prevalence of UTI and SBU in dogs with chronic kidney disease (CKD) is not known. The objectives of this study were to retrospectively evaluate the prevalence of positive urine cultures in dogs with CKD, and to further categorize these patients as having SBU, clinical UTI, or pyelonephritis.