Author: Liu, Zhida; Zhou, Hang; Wang, Wenjun; Tan, Wenjie; Fu, Yang-Xin; Zhu, Mingzhao
Title: A novel method for synthetic vaccine construction based on protein assembly Document date: 2014_12_1
ID: 2tazu4y6_4
Snippet: Dendritic cell (DC) targeting has emerged as an important strategy for vaccine development due to the increasing recognition of this small population of cells in both cellular and humoral immune responses [8] [9] [10] [11] [12] [13] . DEC205 is a C-type lectin endocytic receptor that is highly expressed on CD8a 1 DCs in mice 14 and on CD141 1 DCs in humans 15 . An antibody against DEC205 has been developed as a useful targeted delivery molecule. .....
Document: Dendritic cell (DC) targeting has emerged as an important strategy for vaccine development due to the increasing recognition of this small population of cells in both cellular and humoral immune responses [8] [9] [10] [11] [12] [13] . DEC205 is a C-type lectin endocytic receptor that is highly expressed on CD8a 1 DCs in mice 14 and on CD141 1 DCs in humans 15 . An antibody against DEC205 has been developed as a useful targeted delivery molecule. When conjugated to this antibody, an antigen can be efficiently delivered to DCs, an approach that has been found to be superior in mediating both cytotoxic T cell responses [16] [17] [18] and antibody responses 19, 20 .
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