Author: Weishan Huang; Sabrina Solouki; Chavez Carter; Song-Guo Zheng; Avery August
Title: Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages Document date: 2018_6_30
ID: ivyp5cgz_23
Snippet: Mice carrying the IL-10 GFP /Foxp3 RFP dual reporters were exposed intranasally to house dust mite 234 (HDM) protein extract (as a model of allergic asthma), Saccharopolyspora rectivirgula (SR) (as a 235 model of HP/farmers' lung disease), or infected intranasally with WSN/flu virus (as a model of 236 influenza infection). We observed significant percentages of IL-10-producing T cells in the lung 237 tissue of mice exposed HDM (Fig. 3A) , SR (Fig.....
Document: Mice carrying the IL-10 GFP /Foxp3 RFP dual reporters were exposed intranasally to house dust mite 234 (HDM) protein extract (as a model of allergic asthma), Saccharopolyspora rectivirgula (SR) (as a 235 model of HP/farmers' lung disease), or infected intranasally with WSN/flu virus (as a model of 236 influenza infection). We observed significant percentages of IL-10-producing T cells in the lung 237 tissue of mice exposed HDM (Fig. 3A) , SR (Fig. 3C) , or WSN/flu virus (Fig. 3E) . These IL-10-238 producing T cells all co-expressed high levels of LAG3 and CD49b, and include Foxp3 + CD4 + , 239 . CC-BY-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/359547 doi: bioRxiv preprint Foxp3 -CD4and CD8 + subsets in all disease models analyzed (Fig. 3) . However, the relative 240
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