Author: Alba Grifoni; John Sidney; Yun Zhang; Richard H Scheuermann; Bjoern Peters; Alessandro Sette
Title: Candidate targets for immune responses to 2019-Novel Coronavirus (nCoV): sequence homology- and bioinformatic-based predictions Document date: 2020_2_20
ID: 8p1agcm2_4
Snippet: Comparison of a consensus 2019-nCoV protein sequence to sequences for SARS-CoV, MERS-CoV and bat-SL-CoVZXC21 revealed a high degree of similarity (expressed as % identity) between 2019-nCoV, bat-SL-CoVZXC21 and SARS-CoV, but more limited similarity with MERS-CoV (Figure 1 ). In conclusion, SARS-Cov is the closest related virus to 2019-nCoV for which a significant number of epitopes has been defined in humans (and other species), and that also cau.....
Document: Comparison of a consensus 2019-nCoV protein sequence to sequences for SARS-CoV, MERS-CoV and bat-SL-CoVZXC21 revealed a high degree of similarity (expressed as % identity) between 2019-nCoV, bat-SL-CoVZXC21 and SARS-CoV, but more limited similarity with MERS-CoV (Figure 1 ). In conclusion, SARS-Cov is the closest related virus to 2019-nCoV for which a significant number of epitopes has been defined in humans (and other species), and that also causes human disease with lethal outcomes. Accordingly, in the following analyses we focused on comparing known SARS-CoV epitope sequences to the 2019-nCoV sequence.
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