Selected article for: "non effusive fip and real time"
Author: Osumi, Takafumi; Mitsui, Ikki; Leutenegger, Christian M; Okabe, Ryo; Ide, Kaori; Nishifuji, Koji
Title: First identification of a single amino acid change in the spike protein region of feline coronavirus detected from a coronavirus-associated cutaneous nodule in a cat
  • Document date: 2018_9_20
    • ID: 1o9oqnd6_2
    Snippet: Three studies have reported cutaneous manifestations in cats with FIP. [4] [5] [6] Two of those cases had clinical signs of the non-effusive form of FIP, with ocular and/or kidney involvement, whereas the third case had clinical signs of the mixed form of FIP, with ocular and renal involvement as well as pleural effusion. All three cats in these studies were <2 years old, and they developed papular-to-nodular skin lesions. Histopathologically, th.....
    Document: Three studies have reported cutaneous manifestations in cats with FIP. [4] [5] [6] Two of those cases had clinical signs of the non-effusive form of FIP, with ocular and/or kidney involvement, whereas the third case had clinical signs of the mixed form of FIP, with ocular and renal involvement as well as pleural effusion. All three cats in these studies were <2 years old, and they developed papular-to-nodular skin lesions. Histopathologically, the skin lesions reported previously were characterised by a perivascular pyogranulomatous inflammatory reaction in the dermis to subcutis. The presence of coronavirus antigen in macrophages within the skin lesions was confirmed by immunohistochemistry in all three cases. However, genetic evidence of mutated FCoV in the cutaneous lesions of FIP has not been reported. Here, we describe a feline case in which a nucleotide mutation in the FCoV spike gene was identified by real-time reverse transcription (RT)-PCR in a coronavirus-associated cutaneous nodule. The mutation was consistent with previous FCoV mutations commonly associated with FIP. 7

    Search related documents:
    Co phrase search for related documents
    • coronavirus antigen presence and feline case: 1
    • cutaneous lesion and FIP cutaneous lesion: 1
    • cutaneous nodule and FCoV mutation: 1
    • cutaneous nodule and FCoV spike gene: 1
    • cutaneous nodule and FCoV spike gene nucleotide mutation: 1
    • cutaneous nodule and FIP cat: 1
    • FCoV mutation and FIP cat: 1, 2, 3
    • FCoV spike gene and FIP cat: 1, 2
    • FCoV spike gene nucleotide mutation and FIP cat: 1
    • feline case and FIP cat: 1, 2
    • feline case and FIP mixed form: 1
    • feline case and FIP non effusive form: 1