2016 ACVIM Forum Research Abstract Program

This study suggests individual variation in aspirin response does exist in dogs as assessed by multiple electrode aggregometry. A single low dose (1 mg/kg) of aspirin was not sufficient to cause measurable inhibition of platelet aggregation in healthy dogs and resulted in ASA and SA concentrations that were substantially less than the in vitro EC50. Low-dose (1 mg/kg) aspirin therapy may not be a reliable antithrombotic therapy after only a single dose thus necessitating the potential need for additional therapies during the first 24 hours. Further research looking at higher oral aspirin doses or multiple day dosing is warranted to better establish an in vivo EC50 and determine the predictive value of in vitro EC50 determination prior to commencement of therapy. The differentiation between intestinal lymphoma and inflammatory bowel disease (IBD) can be diagnostically challenging. Anemia is a frequent paraneoplastic syndrome in dogs with lymphoma, and eccentrocytes have also been reported in canine lymphoma. The purpose of this study was to assess the prevalence of anemia and various RBC morphologic anomalies in the peripheral blood of dogs with a diagnosis of lymphoma or IBD, to determine if there is an association with the specific disease and with the severity of lymphoma.