2016 ACVIM Forum Research Abstract Program

We conclude that dogs that are homozygous for the ACE variant have lower baseline levels of ACE activity but still demonstrate ACE inhibition in response to enalapril. Further study is warranted to evaluate the clinical importance of these findings. The Cavalier King Charles Spaniel is one of the most commonly reported breeds of dogs affected with myxomatous mitral valve disease (MMVD). Angiotensin converting enzyme (ACE) inhibitors are frequently recommended for management of dogs with MMVD. However, the benefit of ACE inhibition in MMVD before congestive heart failure has developed is controversial with different studies showing conflicting results. A variable response to ACE inhibitor therapy has also been observed in human beings with heart disease and has been attributed to a polymorphism in the ACE gene. We have previously demonstrated a polymorphism in the canine ACE gene in small breed dogs.