Author: Baum, Alina; García-Sastre, Adolfo
Title: Induction of type I interferon by RNA viruses: cellular receptors and their substrates Document date: 2009_11_1
ID: 4c1nuv2p_19
Snippet: The third member of the RLR family, LGP2, also contains a DExD/H helicase domain but is completely lacking in CARDs and is not able to initiate antiviral signaling. Instead, this protein is thought to act as a regulator of RLR signaling; a negative one for RIG-I induced signaling and a positive one for MDA5 induced signaling......
Document: The third member of the RLR family, LGP2, also contains a DExD/H helicase domain but is completely lacking in CARDs and is not able to initiate antiviral signaling. Instead, this protein is thought to act as a regulator of RLR signaling; a negative one for RIG-I induced signaling and a positive one for MDA5 induced signaling.
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