Author: Darwish, Ilyse; Miller, Chris; Kain, Kevin C.; Liles, W. Conrad
Title: Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza Document date: 2012_1_13
ID: 1rktb6yq_7
Snippet: We evaluated the ability of iNO to improve survival of influenza A/WSN/33 (mouse-adapted H1N1 strain; WSN/33) infected mice. Experimental C57Bl/6 mice were inoculated intranasally with an 80-100% lethal dose of WSN/33 (1000 PFU). At 5 days post-infection, the majority of mice in all experimental groups experienced weight loss ( Fig. 1a and 2a ). At 7 days post-infection, mice began to reach euthanasia criteria (≤80% of day 0 weight), and by day.....
Document: We evaluated the ability of iNO to improve survival of influenza A/WSN/33 (mouse-adapted H1N1 strain; WSN/33) infected mice. Experimental C57Bl/6 mice were inoculated intranasally with an 80-100% lethal dose of WSN/33 (1000 PFU). At 5 days post-infection, the majority of mice in all experimental groups experienced weight loss ( Fig. 1a and 2a ). At 7 days post-infection, mice began to reach euthanasia criteria (≤80% of day 0 weight), and by day 10 post-infection, most mice were euthanized ( Fig. 1b and 2b ). If 20% weight loss was not met by day 10 post-infection, the infection typically resolved, and surviving mice gained weight.
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