Author: Swatek, Kirby N.; Aumayr, Martina; Pruneda, Jonathan N.; Visser, Linda J.; Berryman, Stephen; Kueck, Anja F.; Geurink, Paul P.; Ovaa, Huib; van Kuppeveld, Frank J. M.; Tuthill, Tobias J.; Skern, Tim; Komander, David
Title: Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies Document date: 2018_3_6
ID: 3s86w4iw_11
Snippet: At higher enzyme concentrations, ubiquitin and NEDD8 were also cleaved at an identical site between Arg74 and the C-terminal GlyGly motif, whereas SUMO1 was not cleaved ( Lys residue and renders the ubiquitin/ubiquitin-like protein incompetent toward additional rounds of conjugation......
Document: At higher enzyme concentrations, ubiquitin and NEDD8 were also cleaved at an identical site between Arg74 and the C-terminal GlyGly motif, whereas SUMO1 was not cleaved ( Lys residue and renders the ubiquitin/ubiquitin-like protein incompetent toward additional rounds of conjugation.
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