Author: Swatek, Kirby N.; Aumayr, Martina; Pruneda, Jonathan N.; Visser, Linda J.; Berryman, Stephen; Kueck, Anja F.; Geurink, Paul P.; Ovaa, Huib; van Kuppeveld, Frank J. M.; Tuthill, Tobias J.; Skern, Tim; Komander, David
Title: Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies Document date: 2018_3_6
ID: 3s86w4iw_5
Snippet: Viruses are well-known to counter these defenses and manipulate the regulatory machineries or the modifications themselves (8, 9, 15) . For instance, Crimean Congo hemorrhagic fever virus (CCHFV), severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome coronavirus all encode proteases with dual deISGylase and DUB activity (16) ......
Document: Viruses are well-known to counter these defenses and manipulate the regulatory machineries or the modifications themselves (8, 9, 15) . For instance, Crimean Congo hemorrhagic fever virus (CCHFV), severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome coronavirus all encode proteases with dual deISGylase and DUB activity (16) .
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