Selected article for: "CGGA database and patient survival"
Author: Gao, Mengqi; Lin, Yi; Liu, Xing; Li, Yiming; Zhang, Chuanbao; Wang, Zheng; Wang, Zhiliang; Wang, Yulin; Guo, Zongze
Title: ISG20 promotes local tumor immunity and contributes to poor survival in human glioma
  • Document date: 2018_10_31
    • ID: 6m4q219k_3
    Snippet: To identify the differentially expressed immune-related genes according to IDH status, we compared their expression levels between IDHwt and IDHmut tumors. Genes were analyzed in four groups: LGG in the CGGA database (CGGA-LGG), GBM in the CGGA database (CGGA-GBM), LGG in the TCGA database (TCGA-LGG), and GBM in the TCGA database (TCGA-GBM). Twelve genes with upregulated expression in IDHmut gliomas and 71 genes with upregulated expression in IDH.....
    Document: To identify the differentially expressed immune-related genes according to IDH status, we compared their expression levels between IDHwt and IDHmut tumors. Genes were analyzed in four groups: LGG in the CGGA database (CGGA-LGG), GBM in the CGGA database (CGGA-GBM), LGG in the TCGA database (TCGA-LGG), and GBM in the TCGA database (TCGA-GBM). Twelve genes with upregulated expression in IDHmut gliomas and 71 genes with upregulated expression in IDHwt tumors were found to be significant across all four cohorts ( Figure 1 , Table S1 ). The prognostic value of these genes was further evaluated (Table S2) . Only one gene, ISG20, with up-regulated expression in IDHwt tumors, was found to have a consistently significant influence on patient survival across all groups.

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