Author: Lee, Charlie Wah Heng; Koh, Chee Wee; Chan, Yang Sun; Aw, Pauline Poh Kim; Loh, Kuan Hon; Han, Bing Ling; Thien, Pei Ling; Nai, Geraldine Yi Wen; Hibberd, Martin L.; Wong, Christopher W.; Sung, Wing-Kin
Title: Large-scale evolutionary surveillance of the 2009 H1N1 influenza A virus using resequencing arrays Document date: 2010_2_25
ID: 1rhy8td0_51
Snippet: So far, the sequence diversity of H1N1 2009 influenza virus has been rather limited. From our analysis, it would be possible to resequence all the published isolates using this resequencing approach. However, as antigenic drift is expected to occur, it is likely that the resequencing array would need to be updated at least annually. Updating the array requires only bioinformatics input, and does not require any other additional manufacturing cost.....
Document: So far, the sequence diversity of H1N1 2009 influenza virus has been rather limited. From our analysis, it would be possible to resequence all the published isolates using this resequencing approach. However, as antigenic drift is expected to occur, it is likely that the resequencing array would need to be updated at least annually. Updating the array requires only bioinformatics input, and does not require any other additional manufacturing costs. Thus, this combination of sample amplification primers, low-cost multiplex array and robust interpretation software allows sustainable, rapid, large-scale biosurveillance of the influenza H1N1(2009) virus.
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