Selected article for: "high affinity and SARS infection"
Author: Xin Zeng; Lingfang Li; Jing Lin; Xinlei Li; Bin Liu; Yang Kong; Shunze Zeng; Jianhua Du; Huahong Xiao; Tao Zhang; Shelin Zhang; Jianghai Liu
Title: Blocking antibodies against SARS-CoV-2 RBD isolated from a phage display antibody library using a competitive biopanning strategy
  • Document date: 2020_4_20
    • ID: 4w6caxwu_3
    Snippet: No effective cure or vaccine is currently available for COVID-19. Based on structure information above, blocking SARS-CoV-2 RBD is a rational therapeutic approach. Here we developed a competitive biopanning strategy to efficiently isolate blocking antibodies from phage display antibody libraries. Several high-affinity antibodies targeting SARS-CoV-2 RBD and blocking its binding to ACE2 were isolated, and the top 1 lead exhibited a neutralization .....
    Document: No effective cure or vaccine is currently available for COVID-19. Based on structure information above, blocking SARS-CoV-2 RBD is a rational therapeutic approach. Here we developed a competitive biopanning strategy to efficiently isolate blocking antibodies from phage display antibody libraries. Several high-affinity antibodies targeting SARS-CoV-2 RBD and blocking its binding to ACE2 were isolated, and the top 1 lead exhibited a neutralization activity of SARS-CoV-2 pseudotyped VSV infection.

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