Author: Tornai, David; Furi, Istvan; Shen, Zu T.; Sigalov, Alexander B.; Coban, Sahin; Szabo, Gyongyi
Title: Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice Document date: 2018_10_29
ID: 35jfg45k_31
Snippet: Next, we evaluated the impact of the TREM-1 inhibitors on hepatocyte damage and steatosis in liver. Serum ALT levels obtained during week 5 of the alcohol feeding showed significant increases in alcohol-fed mice compared to PF controls. This ALT increase was attenuated in both TREM-1 inhibitor-treated groups, indicating attenuation of liver injury (Fig. 4A) . Interestingly, vehicle treatment (HDL) also showed a similar protective effect (Fig. 4A).....
Document: Next, we evaluated the impact of the TREM-1 inhibitors on hepatocyte damage and steatosis in liver. Serum ALT levels obtained during week 5 of the alcohol feeding showed significant increases in alcohol-fed mice compared to PF controls. This ALT increase was attenuated in both TREM-1 inhibitor-treated groups, indicating attenuation of liver injury (Fig. 4A) . Interestingly, vehicle treatment (HDL) also showed a similar protective effect (Fig. 4A) .
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