Selected article for: "cell cell and cytokine production"
Author: Lulin Huang; Yi Shi; Bo Gong; Li Jiang; Xiaoqi Liu; Jialiang Yang; Juan Tang; Chunfang You; Qi Jiang; Bo Long; Tao Zeng; Mei Luo; Fanwei Zeng; Fanxin Zeng; Shuqiang Wang; Xingxiang Yang; Zhenglin Yang
Title: Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19
  • Document date: 2020_3_17
    • ID: 2okcuviq_13
    Snippet: patients. Among them, interferon α-inducible protein 27 (IFI27), originally known to involve in innate immunity and to intervene in cell proliferation (22) , was increasingly expressed in many cell types, including CD1C+_B dendritic cells, Table S8 ). These genes were previously shown to regulate cell invasion, migration, proliferation and innate immunity by inhibiting pro-inflammatory cytokine production (27, 28) . In three groups of inpatients.....
    Document: patients. Among them, interferon α-inducible protein 27 (IFI27), originally known to involve in innate immunity and to intervene in cell proliferation (22) , was increasingly expressed in many cell types, including CD1C+_B dendritic cells, Table S8 ). These genes were previously shown to regulate cell invasion, migration, proliferation and innate immunity by inhibiting pro-inflammatory cytokine production (27, 28) . In three groups of inpatients with different conditions, the up-regulated expression of these genes was observed in CD1C+_B dendritic cell, CD1C-CD141dendritic cell, CD141+CLEC9A+ dendritic cell, CD8 cytotoxic T cells, and plasmacytoid dendritic cells. Interestingly, in contrast to the three groups of inpatients, the expression pattern of these genes in the two cured patients was the opposite. In the cured patients, down-regulated expression was detected, indicating that the MAPK signaling pathway was inhibited in these cells. These results indicate that downregulation of the MAPK signal pathway may be one sign of patient recovery.

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